Glyphosate Studies relevant to Human Health
Date Added to website 13th August 2014
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This is an updated list. Grateful thanks to GMOFree USA. Source:
http://gmofreeusa.org/gmos-are-top/gmo-science/glyphosate-studies/
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Arbuckle, T.E.; Lin, Z.& Mery, L.S. (2001). An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives, 109, 851-857.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240415/
K.L. Bassil, MSc, C. Vakil, MD CCFP FCFP, M. Sanborn, MD CCFP FCFP, D.C. Cole, MD MSc FRCPC, J.S. Kaur, MD, K.J. Kerr, MD DIP ENV HEALTH (2007) Cancer health effects of pesticides Can Fam Physician. October; 53(10): 17041711. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2231435/
Benachour N, Sipahutar H, Moslemi S, Gasnier C, Travert C, Sralini GE. (2007) Time- and dose-dependent effects of roundup on human embryonic and placental cells. Arch Environ Contam Toxicol. Jul;53(1):126-33
http://www.ncbi.nlm.nih.gov/pubmed/17486286
Benachour N, Sralini GE. (2009) Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. Chem Res Toxicol. Jan;22(1):97-105.
http://www.ncbi.nlm.nih.gov/pubmed/19105591
Benedetti D, Nunes E, Sarmento M, Porto C, Dos Santos CE, Dias JF, da Silva J. (2013) Genetic damage in soybean workers exposed to pesticides: evaluation with the comet and buccal micronucleus cytome assays. Mutat Res. Apr 15;752(1-2):28-33.
http://www.ncbi.nlm.nih.gov/pubmed/23347873
Bolognesi C, Carrasquilla G, Volpi S, Solomon KR, Marshall EJ. (2009) Biomonitoring of genotoxic risk in agricultural workers from five colombian regions:association to occupational exposure to glyphosate. J Toxicol Environ Health A.2009;72(15-16):986-97. http://www.ncbi.nlm.nih.gov/pubmed/19672767
Chaufan G, Coalova I, Molina Mdel C. (2014) Glyphosate commercial formulation causes cytotoxicity, oxidative effects, and apoptosis on human cells: differences with its active ingredient. Int J Toxicol. 2014 Jan;33(1):29-38. http://www.ncbi.nlm.nih.gov/pubmed/24434723
DBrant, Jeanne (2014) GMOs, Gut Flora, the Shikimate Pathway and Cytochrome Dysregulation. Nutritional Perspectives: Journal of the Council on Nutrition . Jan, Vol. 37 Issue 1, p5-12. 8p. http://web.b.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=01603922&AN=94360210&h=4PCYGUxO52bGE2ivsZ2gu4LxLgOF%2bwYVdAiUYUS9pnuQ5EtUEnsPaHyMqEDF1rtnYJZrr12r831QWVRkz8NW7Q%3d%3d&crl=c
Defarge N, Mesnage R, Gress S, Sralini GE. (2012) Letter to the editor: developmental and reproductive outcomes of roundup and glyphosate in humans and animals. J Toxicol Environ Health B Crit Rev. 2012;15(7):433-7 http://www.tandfonline.com/doi/abs/10.1080/10937404.2012.736857?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.UnvK1Eko7IU
Deo SP, Shetty P. (2012) Accidental chemical burns of oral mucosa by herbicide. JNMA J Nepal Med Assoc. Jan-Mar;52(185):40-2. http://www.ncbi.nlm.nih.gov/pubmed/23279773
Elie-Caille C, Heu C, Guyon C, Nicod L. (2010) Morphological damages of a glyphosate-treated human keratinocyte cell line revealed by a micro- to nanoscale microscopic investigation. Cell Biol Toxicol. Aug;26(4):331-9. http://www.ncbi.nlm.nih.gov/pubmed/20043237
Vincent F Garry, Mary E Harkins, Leanna L Erickson, Leslie K Long-Simpson, Seth E Holland, and Barbara L Burroughs (2002) Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environ Health Perspect. June; 110(Suppl 3): 441449. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241196/
Gasnier C, Dumont C, Benachour N, Clair E, Chagnon MC, Sralini GE (2009) Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology. Aug 21;262(3):184-91. http://www.ncbi.nlm.nih.gov/pubmed/19539684
Gasnier C, Benachour N, Clair E, Travert C, Langlois F, Laurant C, Decroix-Laporte C, Sralini GE. (2010) Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. J Occup Med Toxicol. 2010 Oct 27;5:29 http://www.ncbi.nlm.nih.gov/pubmed/20979644
Jasmine George and Yogeshwer Shukla (2013) Emptying of Intracellular Calcium Pool and Oxidative Stress Imbalance Are Associated with the Glyphosate-Induced Proliferation in Human Skin Keratinocytes HaCaT Cells ISRN Dermatol. 2013; 825180. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773425/#!po=65.3846
Heu C, Berquand A, Elie-Caille C, Nicod L. (2012) Glyphosate-induced stiffening of HaCaT keratinocytes, a Peak Force Tapping study on living cells. J Struct Biol. Apr;178(1):1-7.http://www.ncbi.nlm.nih.gov/pubmed/22369932
Celine Heu, Celine Elie-Caille, Virginie Mougey, Sophie Launay, Laurence Nicod (2012) A step further toward glyphosate-induced epidermal cell death: Involvement of mitochondrial and oxidative mechanisms Environmental Toxicology and Pharmacology Volume 34, Issue 2, September 2012, Pages 144153 http://www.sciencedirect.com/science/article/pii/S1382668912000300
Hokanson R, Fudge R, Chowdhary R, Busbee D. (2007) Alteration of estrogen-regulated gene expression in human cells induced by the agricultural and horticultural herbicide glyphosate. Hum Exp Toxicol. Sep;26(9):747-52. http://www.ncbi.nlm.nih.gov/pubmed/17984146
Malin Hultberg (2007) Cysteine turnover in human cell lines is influenced by glyphosate Environmental Toxicology and Pharmacology Volume 24, Issue 1, July, Pages 1922 http://www.sciencedirect.com/science/article/pii/S1382668907000208
Jayasumana, Channa; Gunatilake, Sarath; Senanayake, Priyantha. (2014) Glyphosate, Hard Water and Nephrotoxic Metals: Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka? Int. J. Environ. Res. Public Health 11, no. 2: 2125-2147. http://www.mdpi.com/1660-4601/11/2/2125
Koller VJ, Fürhacker M, Nersesyan A, Mišík M, Eisenbauer M, Knasmueller S. (2012) Cytotoxic and DNA-damaging properties of glyphosate and Roundup in human-derived buccal epithelial cells. Arch Toxicol. May;86(5):805-13. http://www.ncbi.nlm.nih.gov/pubmed/22331240
Krüger, M., Schledorn, P., Schrödl, W., Hoppe, H. W., & Lutz, W. (2014). Detection of Glyphosate Residues in Animals and Humans. J Environ Anal Toxicol, 4(210), 2161-0525. http://omicsonline.org/open-access/detection-of-glyphosate-residues-in-animals-and-humans-2161-0525.1000210.pdf
Lioi MB, Scarfi MR, Santoro A, Barbieri R, Zeni O, Salvemini F, Di Berardino D, Ursini MV (1998) Cytogenetic damage and induction of pro-oxidant state in human lymphocytes exposed in vitro to gliphosate, vinclozolin, atrazine, and DPX-E9636. Environ Mol Mutagen. 32(1):39-46. http://www.ncbi.nlm.nih.gov/pubmed/9707097
Mariager TP, Madsen PV, Ebbehøj NE, Schmidt B, Juhl A. (2013) Severe adverse effects related to dermal exposure to a glyphosate-surfactant herbicide. Clin Toxicol (Phila). 2013 Feb;51(2):111-3. http://www.ncbi.nlm.nih.gov/pubmed/23360343
Martinez A, Reyes I, Reyes N (2007) Cytotoxicity of the herbicide glyphosate in human periphera lblood mononuclear cells. Biomedica. Dec;27(4):594-604. http://www.ncbi.nlm.nih.gov/pubmed/18320126
Daniela Merlotti, Luigi Gennari, Konstantinos Stolakis, and Ranuccio Nuti (2011) Aromatase Activity and Bone Loss in Men. Journal of Osteoporosis
Volume 2011, Article ID 230671, 11 pages http://www.hindawi.com/journals/jos/2011/230671/
R Mesnage, E Clair, J Spiroux de Vendmois, G-E Sralini (2010) Two cases of birth defects overlapping Stratton-Parker syndrome after multiple pesticide exposure Occup Environ Med;67:359 http://oem.bmj.com/content/67/5/359.extract
Robin Mesnage, Christian Moesch, Rozenn Le Grand, Guillaume Lauthier, Jol Spiroux de Vendmois, Steeve Gress, Gilles-Eric Sralini (2012) Glyphosate Exposure in a Farmers Family Journal of Environmental Protection, 3, 1001-1003 http://www.scirp.org/journal/PaperDownload.aspx?paperID=22645
Mesnage R, Bernay B, Sralini GE. (2012) Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity. Toxicology. Sep 21. pii: S0300-483X(12)00345-9. http://www.ncbi.nlm.nih.gov/pubmed/23000283
R. Mesnage, E. Clair, S. Gress, C. Then, A. Szkács, G.-E. Sralini (2013) Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide Journal of Applied Toxicology Volume 33, Issue 7, pages 695699, July
http://onlinelibrary.wiley.com/doi/10.1002/jat.2712/abstract
Robin Mesnage, Nicolas Defarge, Jol Spiroux de Vendmois, and Gilles-Eric Sralini (2013) Major pesticides are more toxic to human cells than their declared active principles BioMed Research International downloads.hindawi.com/journals/bmri/aip/179691.pdf
Monroy CM, Corts AC, Sicard DM, de Restrepo HG. (2005) [Cytotoxicity and genotoxicity of human cells exposed in vitro to glyphosate]. Biomedica. Sep;25(3):335-45. http://www.ncbi.nlm.nih.gov/pubmed/16276681
Wendy A Morley, Stephanie Seneff (2014) Diminished brain resilience syndrome: A modern day neurological pathology of increased susceptibility to mild brain trauma, concussion, and downstream neurodegeneration. Surg Neurol Int, 5:97 http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2014;volume=5;issue=1;spage=97;epage=97;aulast=Morley
Sara Mostafalou, Mohammad Abdollahi (2013) Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives. Toxicology and Applied Pharmacology Volume 268, Issue 2, 15 April 2013, Pages 157177 http://www.sciencedirect.com/science/article/pii/S0041008X13000549
Teresinha de Jesus C. Neiva; Ana Carolina R. Moraes; Rafaella SchwyzerI; Cidnia de Lourdes Vituri; Tania Rubia F. Rocha; Diana M. Fries; Márcio A. Silva; Aloisio Luiz Benedetti (2010) In vitro effect of the herbicide glyphosate on human blood platelet aggregation and coagulation Rev. Bras. Hematol. Hemoter. vol.32 no.4 http://www.scielo.br/pdf/rbhh/2010nahead/aop87010.pdf
Paz-y-Miño, C.,Sánchez, M.E., Arvalo, M., Muñoz,M.J., Witte, T., De-la-Carrera, G.O., Leone, P.E. (2007) Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate. Genetics and Molecular Biology 30,456-460. http://www.scielo.br/pdf/gmb/v30n2/a26v30n2.pdf
Potrebi O, Jovi-Stosi J, Vucini S, Tadi J, Radulac M (2009) [Acute glyphosate-surfactant poisoning with neurological sequels and fatal outcome]. Vojnosanit Pregl. Sep;66(9):758-62. http://www.ncbi.nlm.nih.gov/pubmed/19877558
Potti, A. and I. Sehgal, Exposure to pesticides increases levels of uPA and uPAR in pre- malignant human prostate cells. Environ Toxicol Pharmacol, 2005. 19(2): p. 215-9. http://www.sciencedirect.com/science/article/pii/S1382668904001383
Poulsen, M.S., Rytting, E., Mose, T., Knudsen, L.E. (2000) Modeling placental transport : correlation of invitro BeWo cell permeability and exvivo human placental perfusion. Toxicol. in Vitro 23,13801386. http://www.ncbi.nlm.nih.gov/pubmed/19647068
Richard S, Moslemi S, Sipahutar H, Benachour N, Seralini GE. (2005) Differential effects of glyphosate and roundup on human placental cells and aromatase. Environ Health Perspect. Jun;113(6):716-20.
http://www.ncbi.nlm.nih.gov/pubmed/15929894
Roberts DM, Buckley NA, Mohamed F, Eddleston M, Goldstein DA, Mehrsheikh A, Bleeke MS, Dawson AH. (2010) A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning. Clin Toxicol (Phila). Feb;48(2):129-36.http://www.ncbi.nlm.nih.gov/pubmed/20136481
Rull RP, Ritz B, Shaw GM. (2004) Neural tube defects and maternal residential proximity to agricultural pesticide applications. .Epidemiology. July, 15(4): S188. 33. http://journals.lww.com/epidem/Fulltext/2004/07000/Neural_Tube_Defects_and_Maternal_Residential.499.aspx
Rull RP, Ritz B, Shaw GM. (2006) Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am J Epidemiol. Apr 15; 163(8): 743-753. http://www.ncbi.nlm.nih.gov/pubmed/16495467
Salvagni, J., R.Z. Ternus, and A.M. Fuentefria. (2011) Assessment of the Genotoxic Impact of Pesticides on Farming Communities in the Countryside of Santa Catarina State, Brazil. Genetics and Molecular Biology 34, no. 1 : 122-26. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085357/
Anthony Samsel and Stephanie Seneff (2013) Glyphosates Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases Entropy 2013, 15(4), 1416-1463
http://www.mdpi.com/1099-4300/15/4/1416
Sato C, Kamijo Y, Yoshimura K, Ide T. (2011) Aseptic meningitis in association with glyphosate-surfactant herbicide poisoning. Clin Toxicol (Phila). Feb;49(2):118-20.http://www.ncbi.nlm.nih.gov/pubmed/21370950
Savitz, D.A., Arbuckle, T., Kaczor, D., Curtis, K.M. 1997. Male pesticide exposure and pregnancy outcome. Am. J. Epidemiol. 146, 10251036. http://www.ncbi.nlm.nih.gov/pubmed/9420527
Slager RE, Simpson SL, Levan TD, Poole JA, Sandler DP, Hoppin JA. (2010) Rhinitis associated with pesticide use among private pesticide applicators in the agricultural health study. J Toxicol Environ Health A. ;73(20):1382-93.
http://www.ncbi.nlm.nih.gov/pubmed/20818537
Thongprakaisang S, Thiantanawat A, Rangkadilok N, Suriyo T, Satayavivad J. (2013) Glyphosate induces human breast cancer cells growth via estrogen receptors. Food Chem Toxicol. Sep;59:129-36. http://www.ncbi.nlm.nih.gov/pubmed/23756170
NHL/Cancer(Glyphosate)
A J De Roos, S Zahm, K Cantor, D Weisenburger, F Holmes, L Burmeister, and A Blair (2003) Integrative assessment of multiple pesticides as risk factors for non-Hodgkins lymphoma among men Occup Environ Med. September; 60(9): e11.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1740618/
De Roos AJ, Blair A, Rusiecki JA, Hoppin JA, Svec M, Dosemeci M, Sandler DP, Alavanja MC. (2005) Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ Health Perspect. Jan;113(1):49-54. http://www.ncbi.nlm.nih.gov/pubmed/15626647
Eriksson M, Hardell L, Carlberg M, Akerman M. (2008) Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis. Int J Cancer. Oct 1;123(7):1657-63 http://www.ncbi.nlm.nih.gov/pubmed/18623080
Hardell, L., Eriksson ,M.A. (1999) Case-control study of non-Hodgkin lymphoma and exposure to pesticides. Cancer 85,135360. http://www.ncbi.nlm.nih.gov/pubmed/10189142
Hardell L, Eriksson M, Nordstrom M. (2002) Exposure to pesticides as risk factor for non-Hodgkins lymphoma and hairy cell leukemia: pooled analysis of two Swedish case-control studies. Leuk Lymphoma. May;43(5):1043-9 http://www.ncbi.nlm.nih.gov/pubmed/12148884
Schinasi L, Leon ME (2014) Non-hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. Int J Environ Res Public Health. Apr 23;11(4):4449-527. http://www.ncbi.nlm.nih.gov/pubmed/24762670
Parkinsonism(Glyphosate)
Barbosa ER, Leiros da Costa MD, Bacheschi LA, Scaff M, Leite CC. (2001) Parkinsonism after glycine-derivate exposure. Mov Disord. May;16(3):565-8. http://www.ncbi.nlm.nih.gov/pubmed/11391760
da Costa Mdo D, Gonçalves LR, Barbosa ER, Bacheschi LA. (2003) [Neuroimaging abnormalities in parkinsonism: study of five cases]. Arq Neuropsiquiatr. Jun;61(2B):381-6. http://www.ncbi.nlm.nih.gov/pubmed/12894271
Wang G, Fan XN, Tan YY, Cheng Q, Chen SD. (2011) Parkinsonism after chronic occupational exposure to glyphosate. Parkinsonism Relat Disord. Jul;17(6):486-7. http://www.ncbi.nlm.nih.gov/pubmed/21367645