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IARC publishes full glyphosate/cancer report

Date Added to website 9th August 2015

IARC publishes full glyphosate/cancer report

The full IARC Report on Glyphosate and Cancer has now been published as part of a much larger Report dealing with a wide range of substances. It has clearly been rushed through the publication process, having previously been planned for publication in the spring of next year. Probably the Monsanto pronouncement that the report was "junk science" before that august corporation had even read the text, encouraged the publishers to get a move on. It appears very comprehensive and careful, and is 92 pp long, with a vast number of references -- only relating to publicly available and peer-reviewed sources. So Monsanto's secret studies, which have not been released into the public domain, are ignored by IARC. Quite right too. If anybody round here does junk science, it is Monsanto........

92-page glyphosate report published by IARC (WHO)


6. Evaluation

6.1 Cancer in humans
There is limited evidence in humans for the carcinogenicity of glyphosate. A positive association has been observed for non-Hodgkin lymphoma.

6.2 Cancer in experimental animals
There is sufficient evidence in experimental animals for the carcinogenicity of glyphosate.

6.3 Overall evaluation
Glyphosate is probably carcinogenic to humans (Group 2A).

6.4 Rationale
In making this overall evaluation, the Working Group noted that the mechanistic and other relevant data support the classification of glyphosate in Group 2A.
In addition to limited evidence for the carcinogenicity of glyphosate in humans and sufficient evidence for the carcinogenicity of glyphosate in experimental animals, there is strong evidence that glyphosate can operate through two key characteristics of known human carcinogens, and that these can be operative in humans. Specifically:

• There is strong evidence that exposure to glyphosate or glyphosate-based formulations is genotoxic based on studies in humans in vitro and studies in experimental animals.

One study in several communities in individuals exposed to glyphosate-based formulations also found chromosomal damage in blood cells; in this study, markers of chromosomal damage (micronucleus formation) were significantly greater after exposure than before exposure in the same individuals.

• There is strong evidence that glyphosate, glyphosate-based formulations, and aminomethylphosphonic acid can act to induce oxidative stress based on studies in experimental animals, and in studies in humans in vitro. This mechanism has been challenged experimentally by administering antioxidants, which abrogated the effects of glyphosate on oxidative stress. Studies in aquatic species provide additional evidence for glyphosate-induced oxidative stress.